Paul M L Janssen Selected Research

Contracture

8/2014	Decrease in sarcoplasmic reticulum calcium content, not myofilament function, contributes to muscle twitch force decline in isolated cardiac trabeculae.
1/2013	The positive inotropic effect of pyruvate involves an increase in myofilament calcium sensitivity.
1/2013	Effect of muscle length on cross-bridge kinetics in intact cardiac trabeculae at body temperature.
1/2012	Staurosporine inhibits frequency-dependent myofilament desensitization in intact rabbit cardiac trabeculae.
5/2010	Increased phosphorylation of tropomyosin, troponin I, and myosin light chain-2 after stretch in rabbit ventricular myocardium under physiological conditions.
1/2010	Effects of hydroxyl radical induced-injury in atrial versus ventricular myocardium of dog and rabbit.
9/2009	Impairment of diastolic function by lack of frequency-dependent myofilament desensitization rabbit right ventricular hypertrophy.
5/2007	Frequency-dependent acceleration of relaxation involves decreased myofilament calcium sensitivity.
5/2006	Measurement of myofilament calcium sensitivity at physiological temperature in intact cardiac trabeculae.
10/2002	Physiological determinants of contractile force generation and calcium handling in mouse myocardium.

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Paul M L Janssen Research Topics

Disease

30	Heart Failure 01/2021 - 01/2002
14	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2021 - 12/2005
12	Muscular Dystrophies (Muscular Dystrophy) 12/2020 - 04/2007
12	Contracture 08/2014 - 01/2002
11	Cardiomyopathies (Cardiomyopathy) 12/2020 - 12/2005
9	Cardiomegaly (Heart Hypertrophy) 11/2017 - 01/2012
7	Hypertrophy 01/2021 - 12/2007
7	Fibrosis (Cirrhosis) 01/2021 - 01/2012
7	Cardiac Arrhythmias (Arrythmia) 01/2019 - 06/2013
5	Cardiovascular Diseases (Cardiovascular Disease) 11/2021 - 01/2016
5	Reperfusion Injury 01/2019 - 05/2002
4	Myocardial Infarction 01/2021 - 12/2006
4	Inflammation (Inflammations) 01/2021 - 04/2007
4	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 10/2018 - 03/2004
4	Hypertension (High Blood Pressure) 11/2017 - 12/2012
3	Heart Diseases (Heart Disease) 01/2021 - 12/2018
3	Atrial Fibrillation 10/2020 - 09/2007
2	Neoplasms (Cancer) 11/2021 - 01/2021
2	Necrosis 12/2018 - 04/2007
2	Left Ventricular Dysfunction 01/2016 - 06/2015
2	Stroke (Strokes) 09/2012 - 12/2006
2	Muscular Diseases (Myopathy) 08/2011 - 11/2009
1	Hypothyroidism 01/2022
1	Euthyroid Sick Syndromes (Euthyroid Sick Syndrome) 01/2022
1	Ventricular Premature Complexes (Premature Ventricular Contraction) 01/2022
1	Nervous System Diseases (Neurological Disorders) 11/2021
1	Alzheimer Disease (Alzheimer's Disease) 11/2021
1	Atherosclerosis 01/2021
1	Weight Gain 12/2020
1	Osteoporosis 12/2020
1	Bradycardia 01/2020
1	Muscle Weakness 01/2020
1	Ischemia 01/2019
1	Heart Valve Diseases (Valvular Heart Disease) 01/2019
1	Pulmonary Arterial Hypertension 03/2018
1	Right Ventricular Hypertrophy 01/2017
1	Ventricular Tachycardia 01/2017

Drug/Important Bio-Agent (IBA)

14	Proteins (Proteins, Gene)FDA Link 01/2020 - 07/2007
13	DystrophinIBA 12/2020 - 12/2005
13	CalciumIBA 01/2018 - 01/2002
6	Thyroxine (Levothyroxine)FDA LinkGeneric 01/2022 - 01/2012
5	Pyruvic Acid (Pyruvate)IBA 01/2013 - 01/2002
4	Adrenergic Agents (Adrenergic Drugs)IBA 01/2022 - 01/2002
4	Isoproterenol (Isoprenaline)FDA LinkGeneric 12/2018 - 05/2006
4	UtrophinIBA 01/2018 - 08/2011
4	PotassiumIBA 01/2013 - 05/2007
4	hydroxide ionIBA 09/2012 - 05/2002
4	Hydroxyl RadicalIBA 09/2012 - 05/2002
3	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 11/2021 - 11/2017
3	Memantine (Namenda)FDA Link 11/2021 - 11/2017
3	Messenger RNA (mRNA)IBA 01/2021 - 03/2018
3	Adenosine (Adenocard)FDA LinkGeneric 01/2021 - 08/2016
3	Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA 12/2020 - 01/2016
3	Myosins (Myosin)IBA 01/2020 - 01/2013
3	Mineralocorticoid Receptor AntagonistsIBA 01/2019 - 01/2016
3	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2018 - 01/2015
3	Spironolactone (Aldactone)FDA LinkGeneric 01/2016 - 08/2011
3	Claudin-5IBA 05/2015 - 07/2008
3	Lisinopril (Prinivil)FDA LinkGeneric 01/2015 - 08/2011
2	N-Methylaspartate (NMDA)IBA 11/2021 - 11/2017
2	MicroRNAs (MicroRNA)IBA 01/2021 - 01/2020
2	AldosteroneIBA 12/2020 - 01/2018
2	CalpainIBA 01/2019 - 01/2016
2	Pharmaceutical PreparationsIBA 01/2019 - 11/2018
2	AnkyrinsIBA 10/2018 - 01/2016
2	Sarcoglycans (beta Sarcoglycan)IBA 01/2016 - 07/2013
2	CatecholaminesIBA 11/2015 - 01/2002
2	Adenosine Triphosphatases (ATPase)IBA 08/2014 - 07/2007
2	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 06/2013 - 05/2013
2	Pravastatin (Pravachol)FDA LinkGeneric 06/2013 - 01/2012
1	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 01/2022
1	Glutamic Acid (Glutamate)FDA Link 11/2021
1	Polysaccharides (Glycans)IBA 01/2021
1	ActomyosinIBA 01/2021
1	Adrenergic Receptors (Adrenergic Receptor)IBA 01/2021
1	6-methyladenineIBA 01/2021
1	Histones (Histone)IBA 01/2021
1	AntibodiesIBA 01/2021
1	N-glycolylneuraminic acidIBA 01/2021
1	AngiotensinsIBA 12/2020
1	finerenoneIBA 12/2020
1	Adrenal Cortex Hormones (Corticosteroids)IBA 12/2020
1	Ion Channels (Ion Channel)IBA 01/2020
1	Cardiac MyosinsIBA 01/2019
1	SpectrinIBA 01/2019
1	Carrier Proteins (Binding Protein)IBA 01/2019
1	Protein Kinases (Protein Kinase)IBA 12/2018
1	Cardiotonic Agents (Cardiac Stimulants)IBA 12/2018
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 11/2018
1	cytidylyl-(3'-5')-cytidine (CpC)IBA 10/2018
1	MineralocorticoidsIBA 01/2018
1	Transforming Growth Factor beta (TGF-beta)IBA 11/2017
1	Propylthiouracil FDA Link 01/2017
1	zacoprideIBA 01/2017

Therapy/Procedure

3	Therapeutics 05/2015 - 01/2002
2	Intraperitoneal Injections 01/2020 - 01/2015
1	Electrodes (Electrode) 10/2020
1	Subcutaneous Injections 12/2018
1	Heart-Assist Devices 01/2018
1	Heart Transplantation (Grafting, Heart) 01/2018